Seroquel and MDMA (and zoloft)

wingnutlives · 19-03-2008, 09:43

Hi, I used the search engine but couldn't find a thread specific to my question. So my situation is... I was on zoloft for a year and a half, but by this weekend I will have been off it for a couple weeks. I basically stopped taking it because it wasn't working for me, and before I stopped completely I had been taking it once every two or three days anyway.
I just got prescribed Seroquel for anxiety (not psychosis or schizophrenia) but have only taken it once... I'll take it again tonight, but then I might go without it until the weekend is over.

Basically my question is: will using seroquel only twice in the past week inhibit the high if I roll this Saturday? What if I've been off zoloft for a couple weeks, would it still have any effect on the roll? Also, should I avoid any SSRI type herbs like St. John's Wort? I haven't rolled in more than a year so I want it to be good!

Thanks!

Inedible · 19-03-2008, 10:25

We also have a directory that is a bit easier to use than the search engine. The link to the directory is stickied at the top of our forum -- and there is an entry for Seroquel. Have you checked it yet?

That said, the half-life of Seroquel is six hours. It's not an SSRI, and it'll be completely out of your system in a day. Most people take about a week or so after discontinuing SSRI therapy to be able to roll properly, but since you've been on it for so long, it could take longer. I can't say for sure you'll have a decent experience, but you'll probably be fine. As for St. John's Wort, it's honestly such a weak SSRI that it probably won't even matter in either case -- I wouldn't even bother taking it period.

Also, consider the fact that you were on SSRI therapy because you had depression issues. Was this a situational depression, meaning, was it because of a specific event, or have you been depressed constantly without reason? If it's the latter case, taking MDMA might exacerbate your depression issues again, now that you aren't on SSRIs. Think about that before you roll again.

wingnutlives · 19-03-2008, 10:39

Thanks, I'll check out the directory... I didn't notice it before, I've always just used the search engine.

Well, I was taking the SSRI because of anxiety, and also my serotonin was pretty low from when I'd done E a lot in the past. I dont' have depression specifically, but I do have seasonal affective disorder (winter depression). I actually stopped taking E for a year because I didn't want to risk fucking up my serotonin, but I decided I would try it again just once and see how it goes. I'm going to take one zoloft right after I come down, because it's supposed to protect some of the receptors... along with super-antioxidants, and other preventive/healthy things. Hopefully it'll go well!

Inedible · 19-03-2008, 10:41

It won't protect the receptors significantly -- they've done studies showing that it's pretty useless in that regard. It may help you feel better, though, some people swear by taking SSRIs for a few days after rolling. Antioxidants are your best bet. Those will help the most in protecting your brain.

montsealavern · 19-03-2008, 22:15

i have to agree with above guy. i have to advice you to avoid rolling if you are troubled by anxiety moods. roll will exacerbate those anxiety outbursts. you are looking to leave meds, and i understand that but the only lasting effects of a roll will be to put you on more medication. it have to be another fun in the party. lol,. take it easy. have fun.

Inedible · 19-03-2008, 22:42

Well, if she's sorted out the issues that caused her to be depressed, she may not have a problem. If she was just on SSRI therapy without counseling, hoping that the drugs will do all the hard work for her, then that's another story. SSRI therapy needs to be coupled with counseling to be effective, in my opinion. You can cure depression, but putting a chemical band-aid on the problem doesn't help unless you're actively seeking out and dealing with the root of the mental issues concurrently.

wingnutlives · 25-03-2008, 10:28

I thought I'd give an update.

Well, I did roll. I stopped taking seroquel about a day before, and hadn't had zoloft for about two weeks. At first I took half a pill, and it really didn't do much. Taking the other half gave me a weak roll. I ended up having to take TWO pills in all to get fully rolling (half a pill used to do it for me), but it wasn't like I remembered. I wasn't completely ecstatic or euphoric like I used to be, and definitely not as chatty - I was just very content, felt some affection for everyone there, and the air seemed softer.

I'm not sure if the pills themselves (green buddhas) were weak, or if the zoloft was somehow still in my system. I also took klonopin while rolling, and that might have affected it somehow. I'm not complaining, cuz they were clean pills and I had a great time, but it was a lot more mellow than I was expecting.

I'm taking my zoloft for the next few days, eating lots of healthy food and anti-oxidant drinks, and taking seroquel at night. It's been two days and so far I've felt great, no negative aftereffects so far. I might not have lost much serotonin because I didn't roll that hard.

pkt · 25-03-2008, 10:33

Seroquel is not a problem, i often take my dose on the comedown....

Inedible · 25-03-2008, 17:12

You've been taking Zoloft for a long time -- your brain chemistry might still not be normalized. The Klonopin might have dulled it, and the pills might have been somewhat weak -- both those are likely, but who knows. At least it worked a little, I guess.

I bet you anything in a month or two of not taking Zoloft, with the proper pills, you'll have a great roll.

Just be wary of rebound depression.

purplefirefly · 26-03-2008, 01:00

^^

I agree with this completely.

It can take awhile for your brain to "normalize" again after being on anti-depressants/anti psychotics. The longer you can wait after you go off of them the less chance you could experience interference from the anti depressants.

Just thought I would also mention that it's never a good idea to stop taking your medication cold turkey just to roll. If you want to go off the med then please do it with the help of your physician.

wingnutlives · 28-03-2008, 00:35

Oh yeah, I didn't stop taking zoloft just to roll. I had stopped because it wasn't working very well, and then I thought "hey, maybe I should roll again and see what it's like" because I had almost forgotten what it was like.
I got a little rebound depression this week, but I've got meds to manage it, and since it's spring break I have plenty of time to sleep and eat right. I don't think I'll roll again for quite a while, though, probably another year at least.

JoKeRTheProbleM · 09-04-2008, 22:11

Im gonna give you an example of a few experiences my girlfriend has had with MDMA and Seroquil . My girlfriend ALWAYS has problems sleeping the night that we roll. She would take 50-100mg pills of seroquil at night to help her sleep. She would wake up in the morning andshe would feel a lil off. And without fail, everytime she would stand up for the following 12-14hrs she would get real light headed with blured vision, and on a few occasions shes actually passed out and found herself picking herself up off the floor not knowing what happened. So since the last time she passed out, she has discontinued the use of Seroquil after rolling. Since then she has not had a severe light headed spell and she hasnt passed out at all. My guess is the combination of the two had some effect on her that wasn't good. So my suggestion is try trial an error...see how u feel when u take Seroquil after rolling. If you feel shitty, then discontinue the use. Personally myself, i have taken seroquil after rollin and ive felt fine overall.